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96%min PDRN
Nanjing Gemsen
Introduction：
Product Name | Polydeoxyribonucleotide(PDRN) |
INCI Name | Sodium DNA; Polydeoxyribonucleotide |
Appearance | White or off-white powder or fibre polymer, particle |
Grade | Cosmetic Grade |
Materials | Male Salmon |
Sample | Available |
PDRN (Polydeoxyribonucleotide, INCI: Sodium DNA) is a biotechnologically derived polymer obtained from male salmon (Oncorhynchus keta) DNA. Unlike many surface‑level actives, it supplies nucleotide building blocks that naturally support fibroblast activity and local tissue maintenance – which explains why it has become a go‑to ingredient in premium aesthetic and daily skincare ranges.
Salmon DNA shares high biocompatibility with human skin, and over a decade of published studies backs its regenerative‑oriented profile. The result: a reliable, well‑documented active for formulators aiming at anti‑aging, post‑procedure support, and sensitive skin solutions.
Specification:
Application:
Background – After needling or laser, the skin barrier is temporarily open, creating a window for deeper delivery. Clinics and home‑use devices need sterile, well‑tolerated actives that assist natural recovery.
How PDRN fits – Applied as a 0.5–2% solution immediately after treatment, PDRN provides a local nucleotide reservoir. The outcome: visibly calmer skin and smoother texture during the recovery window.
Formats – Sterile ampoules, lyophilized vials, hydrogel sheets.
Background – Collagen and elastin production declines with age and UV exposure. Many anti‑aging actives (retinoids, high‑concentration acids) cause irritation, limiting daily use.
How PDRN fits – At 0.1–0.5% in serums or creams, PDRN works gradually alongside the skin’s own renewal pathways. It does not sting or exfoliate, making it ideal for “gentle but effective” daily products targeting fine lines and loss of firmness.
Formats – Lightweight serums, oil‑free gels, emulsion creams.
Background – Redness, tightness, and environmental sensitivity (wind, pollution, temperature shifts) are top consumer complaints. Ingredients that modulate overactive signalling are in high demand.
How PDRN fits – Low doses (0.05–0.2%) activate adenosine A₂A receptors, helping to moderate exaggerated responses. Perfect for soothing toners, barrier creams, or after‑sun recovery.
Formats – Face mists, silicone‑free calming gels, barrier repair balms.
Background – Small cracks from harsh weather, frequent handwashing, or outdoor activities need a clean, nutrient‑rich environment to close naturally. Conventional patches only provide occlusion.
How PDRN fits – In hydrogels or spray‑on dressings, PDRN supplies nucleotide building blocks for keratinocytes. It supports natural closure without acting as a drug.
Formats – Hydrogel patches, spray films, adhesive hydrocolloid strips.
PDRN is stable at pH 5.5–7.0 and tolerates brief heating up to 40°C during emulsification. It pairs excellently with hyaluronic acid, niacinamide, low‑concentration retinoids, and most peptides. Avoid pH <4.0 (e.g., high L‑ascorbic acid) and ethanol >20%. GEMSEN provides detailed compatibility guidance upon request.
Q1: Where does GEMSEN's salmon PDRN come from?
A: Farmed male Oncorhynchus keta (salmon) reproductive tissues. Fully traceable, no endangered or wild stocks. A plant‑based version is also available on request.
Q2: What is the difference between cosmetic grade and injection grade?
A: Injection grade requires much stricter endotoxin limits (<0.5 EU/mL vs. <10 EU/mg for cosmetic grade) plus sterile filtration. GEMSEN primarily supplies cosmetic grade but can arrange injection grade under separate quality agreements.
Q3: What concentration should I use in leave‑on products?
A: 0.05–0.2% for daily soothing serums/creams (no penetration enhancement).
0.5–1.5% for microneedling‑assisted or barrier‑compromised formulas.
Up to 2% is safe but may cause slight tackiness.
Q4: How does salmon PDRN compare to plant PDRN?
A: Salmon PDRN has far more published data and better‑understood receptor affinity. Plant PDRN is still emerging; GEMSEN recommends salmon for most cosmetic applications unless vegan positioning is critical.
Q5: Is PDRN allowed in cosmetics worldwide?
A: Yes. It is accepted as Sodium DNA or Polydeoxyribonucleotide in China, EU, USA, Korea, and Japan. However, claims like "DNA repair" or "gene activation" are not permitted on cosmetic labels. GEMSEN supplies regulatory support files to ensure compliance.
