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PDRN(Sodium DNA)

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Introduction:

Product Name

Polydeoxyribonucleotide(PDRN)

INCI Name

Sodium DNA; Polydeoxyribonucleotide

Appearance

White or off-white powder or fibre polymer, particle

Grade

Cosmetic Grade

Materials

Male Salmon

Sample

Available


Polydeoxyribonucleotide (PDRN), chemical name: Deoxyribonucleotide polymers; alias: Sodium DNA, is a biotechnologically derived polymer. It is sourced specifically from the DNA of Male Salmon.  Characterized as a white or off-white powder or fibrous polymer,  PDRN is slightly soluble in water and insoluble in ethanol with an average molecular weight not exceeding 1000 kDa. Meeting Cosmetic Grade specifications and an in-house quality standard, PDRN is commonly recognized for its tissue regenerative and anti-inflammatory properties, contributing to its use in skincare and wound healing applications.


Specification:

Items Specifications
Appearance

White or off-white powder or fibre polymer, particle

Identification

UV:Ratio of absorbance at 260nm and 280nm 

1.8-2.0 (max.258nm-262nm)

Odor

Characteristic odor

Solubility

Slightly soluble in water, insoluble in ethanol

pH Value

6.0-9.0

Solution appearance

Clear, A600nm≤0.01

Average Molecular Weight

≤1000kD

Protein

NMT 1.0%

Hyperchromicity

NLT 30.0%

Loss on Drying

NMT 10.0%

Heavy Metals

Hg: NMT 0.3ppm

As: NMT 1.5ppm

Pb: NMT 0.5ppm

Cd: NMT 0.2ppm

Microbiological Examination

Aerobic bacterial count: NMT 500cfu/g

Total molds and yeast count: NMT 100cfu/g

Control bacterial inspection

Staphylococcus aureus: Negative

Pseudomonas aeruginosa: Negative

Escherichia coli: Negative

Assay(UV)

NLT 96.0%


Function and Application:

1. PDRN speeds up tissue repair by getting fibroblasts working more actively and encouraging the growth of new blood vessels. It’s used in clinical settings for chronic wounds, diabetic ulcers, and helping with recovery after procedures like microneedling and laser treatments.

2. PDRN spurs the production of collagen and elastin, which makes skin firmer and lessens fine lines. It eases UV-caused photoaging by repairing cells deep down, providing long-term rejuvenation that goes beyond just surface-level effects.

3. By regulating inflammatory responses through activating adenosine A₂A receptors, PDRN calms sensitive skin, reduces redness and irritation, and is good for skin prone to rosacea. It works well for post-procedure recovery and skin conditions that react easily.

4. PDRN strengthens the epidermal barrier and has properties that prevent cell death. It helps treat skin that's been compromised, like in cases of eczema or hyperpigmentation, and makes skin more resilient against environmental stress. It helps barrier restoration and cell protection.

5. It can be used in injectable boosters (mixed with hyaluronic acid), serums used with microneedling, or topical products. This makes it accessible for both clinical use and at-home skincare routines focused on repair, hydration, and improving texture.


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