98% Trans-resveratrol CAS 501-36-0 Antioxidant Anti-aging Longevity Powder

Introduction：

Trans-resveratrol is a plant polyphenol found in grapes, peanuts, and Japanese knotweed. The human body faces constant oxidative stress from normal metabolism and environmental exposure, and its natural defenses decline with age; trans-resveratrol helps support these defenses. Research suggests it may support heart, metabolic, and brain health, but human results vary. It is used in dietary supplements, functional foods, and cosmetic products. Natural food sources contain only small, variable amounts, so standardized extracts are used to ensure consistent dosage. Common commercial grades are standardized to at least 98% trans-resveratrol, though oral bioavailability is low, so formulation strategy matters. Light exposure is a further constraint: UV radiation promotes isomerization to cis-resveratrol and can generate cyclic derivatives, making packaging and photostability central to product design.

Specification:

Application

1. Dietary Supplements

Hard Capsules: Standard two-piece capsules require good flowability and uniform fill weight. Excipients such as microcrystalline cellulose and silicon dioxide are common. Moisture control is critical; desiccant packaging is advised.

Tablets: Direct compression is difficult due to poor compressibility. Wet or dry granulation is often needed. Low-moisture excipients help limit isomerization.

Softgels: Oil-based vehicles such as MCT, olive, or flaxseed oil improve oxidative protection and may support lymphatic transport. Suitable for lipophilic delivery.

Powders and Granules: Used in stick packs or bulk powders. Micronized grades improve dissolution. Taste masking may be required. Light-resistant packaging is essential.

Liquid Formats: Oral drops or suspensions require solubilization via cyclodextrin, emulsion, or micellar systems. pH should remain below 6.8 to limit degradation.

Enhanced-Absorption Grades: Micronized, liposomal, cyclodextrin-complexed, and micellar forms are used to improve dissolution and systemic exposure. Piperine co-formulation is studied but carries interaction considerations.

2. Functional Foods and Beverages

Clear Beverages: Low water solubility limits direct addition. Pre-formed emulsions, cyclodextrin complexes, or nanoencapsulated dispersions are typical. Amber or opaque packaging limits photoisomerization.

Cloudy or Emulsion Beverages: Lipid-based dispersions can carry trans-resveratrol in the oil phase. Antioxidants such as tocopherols may reduce oxidative degradation.

Powdered Drink Mixes: Dry blending is feasible if pH remains below 6.8. Micronized or solubilized grades improve dispersion. Moisture-proof packaging is advised.

Dairy Products: Incorporation into yogurts, milk drinks, or cheese requires compatibility with protein and fat phases. Encapsulation may protect against heat and light during processing.

Baked Goods and Snacks: Bars, cookies, and extruded snacks can be dry-blended or filled. Moderate processing temperatures are preferred. Light-resistant secondary packaging is recommended.

Confectionery: Gummies, chocolates, and chews require moisture control, especially in soft formats. Encapsulation reduces isomerization during storage.

3. Sports Nutrition

Pre-Workout Powders: Rapid dispersion is expected. Standard trans-resveratrol is often replaced with micronized or solubilized forms. May be combined with other polyphenols.

Intra-Workout Drinks: Clear or slightly cloudy beverages require stable dispersion. pH control and light protection are important.

Post-Workout Recovery: Powders, ready-to-drink shakes, or capsules. Lipid-based systems may support absorption. Timing relative to exercise is studied but findings are not yet consistent.

Capsules and Tablets: Convenient for stacked regimens. Micronized or liposomal grades are preferred where absorption speed matters.

Gels and Chews: Portable formats require moisture control and light-resistant packaging. Solubilized forms improve uniformity.

4. Cosmetic and Topical Applications

Serums: Lightweight aqueous or hydroalcoholic bases require solubilization via cyclodextrin or micelles. pH should remain below 6.8. Opaque packaging is advised.

Creams and Lotions: Oil-in-water or water-in-oil emulsions. Trans-resveratrol is dissolved in the oil phase or added as a pre-formed dispersion. Antioxidants help limit degradation.

Masks, Leave-on or rinse-off formats: Encapsulation in nanocapsules or solid lipid nanoparticles improves penetration and photostability.

Sun Care: UV exposure accelerates isomerization. Encapsulation and opaque packaging are essential. Antioxidant co-formulants may offer additional protection.

Color Cosmetics: Foundations, concealers, and lip products require compatibility with pigments and emollients. Encapsulated forms reduce interaction with other ingredients.

5. Pet and Animal Nutrition

Chews and Treats: Soft chews require moisture control to limit isomerization. Inclusion rates based on body weight. Light-resistant packaging is advised.

Powders, Dry blends for mixing into food: Micronized grades improve dispersion. Moisture-proof containers are recommended.

Wet Food: Incorporation into cans or pouches requires heat stability and compatibility with protein and fat phases. Encapsulation may help.

Livestock Feed: Bulk feed applications face cost-per-dose and uniform delivery challenges. Stabilized forms are preferred.

Aquaculture Feed: Water stability and leaching are key concerns. Encapsulation or coating may be required to maintain potency in aquatic environments.

Q&A

Q1. What is the difference between trans-resveratrol and “resveratrol”?

“Resveratrol” does not specify isomer content. Products may contain both trans and cis forms. Trans-resveratrol specifies a material where the trans isomer predominates, typically ≥98%. The trans form is the more stable and better-studied isomer.

Q2. How stable is trans-resveratrol in finished products?

Stability depends on pH, light, and temperature. It is stable under acidic conditions but degrades rapidly above pH 6.8. UV light promotes isomerization to cis-resveratrol and can generate cyclic derivatives. Temperatures above 50 °C accelerate breakdown. Amber or opaque packaging, pH control, and antioxidant co-formulants are recommended.

Q3. Is trans-resveratrol water-soluble?

No. Solubility is approximately 0.05 mg/mL. Beverage applications require pre-formed emulsions, cyclodextrin complexes, or nanoencapsulated dispersions. Capsules and tablets are less affected because dissolution occurs in the gastrointestinal tract.

Q4. What is its regulatory status in major markets?

In the U.S., it is sold as a dietary supplement ingredient under DSHEA. In the EU, it is authorized as a novel food ingredient for food supplements in capsule or tablet form at up to 150 mg per day for adults. Disease-related claims are not permitted.

Q5. Can trans-resveratrol be combined with other ingredients?

Yes, depending on the matrix. Dry blends are generally compatible with most excipients and polyphenol powders. Liquid systems require attention to pH and solubility. Co-encapsulation with other bioactives is possible but remains a formulation research area.

Q6. What is the typical shelf life and storage condition?

Shelf life should be confirmed by stability data. Under cool, dry, light-protected conditions in sealed containers, powder typically remains within specification for 24 months. Moisture and light are the main factors that shorten shelf life.

Q7. Why use standardized trans-resveratrol instead of food sources?

Foods like grapes, peanuts, and berries contain only small, variable amounts. Reaching research-level doses through diet is impractical. Standardized extracts provide consistent purity and dosage.

Q8. Are there any safety considerations for formulators?

Trans-resveratrol has been studied for effects on platelet function. Combining it with anticoagulant or antiplatelet drugs may increase bleeding risk. Formulators should flag this in label warnings and advise consultation with a healthcare provider.