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99%min R-alpha lipoic acid sodium salt
Nanjing Gemsen
176110-81-9
Introduction：
Product Name | R-Alpha Lipoic Acid Sodium Salt |
Appearance | Off-White to light Yellow Powder |
CAS | 176110-81-9 |
Molecular Formula | C8H15NaO2S2 |
Molecular Weight | 230.32 |
Purity | 99.0%min R-Alpha Lipoic Acid Sodium Salt |
Particle Size | 100% through 20 mesh |
| Sample | Available |
MOQ | 1kg |
R-Alpha Lipoic Acid Sodium Salt, also known as Sodium (R)-alpha-lipoate (Na-R-ALA), is the sodium salt of the naturally occurring R-enantiomer of alpha-lipoic acid—a dimercapto compound endogenously synthesized in mitochondria from octanoic acid and widely distributed in plants and animals. The R-form is the biologically active enantiomer, identical to the alpha-lipoic acid produced in human cells. This sodium salt offers distinct physicochemical advantages: sixfold greater thermal stability than free R-lipoic acid, resistance to polymerization at elevated temperatures, and up to 21-fold higher bioavailability. Its amphipathic nature enables functionality in both aqueous and lipid environments. With a minimum purity of 99% and >99.4% R-enantiomer content, this compound is a key ingredient across pharmaceutical, nutraceutical, and cosmetic applications.
Specification:
| Items | Specifications | Results |
| Description | Off-White to light Yellow powder | Conforms |
| Melting Point | 230-250°C | Conforms |
| Solubility (H2O) | Soluble in Water | Conforms |
| Specific Rotation | +85°~+105° | +95.3° |
| Loss On Drying | ≤3.0% | 1.3% |
| Heavy Metals | ≤10 ppm | <10 ppm |
| Total Plate Count | ≤1,000 cfu/g | <10 cfu/g |
| Moulds and Yeasts | ≤100 cfu/g | <10 cfu/g |
| Escherichia Coli | Negative/g | Negative |
| Salmonella | Negative/g | Negative |
| Particle Size | 100% through 20 mesh | Conforms |
| 80% through 80 mesh | Conforms | |
| Bulk Density | N/A | 0.204g/ml |
Assay R-Alpha Lipoic Acid | ≥80.0% (External Standard) | 81.0% |
Assay R-(+)-Alpha Lipoic Acid Sodium | ≥99.0%(Area Normalization) | 99.9% |
| Conclusion | Conformed In-house Standard | |
Application
This form fits well into supplements where stability during manufacturing matters—tableting, encapsulation, and longer shelf life are all easier to manage.
-Sports nutrition – added to pre‑ or post‑workout formulas to support energy use and help counter exercise‑induced oxidative stress
-Healthy aging – used in products focused on mitochondrial function and metabolic health
-Liver support – applied in formulations aimed at liver function through antioxidant pathways
-Metabolic health – included in supplements that support glucose and lipid balance
-Weight management – helps with energy metabolism and fat utilization
-Cognitive function – found in supplements targeting brain health, especially in aging populations
Good stability in water‑based systems makes this ingredient a practical choice for skincare products.
It helps protect the formula itself from oxidation while supporting skin against environmental stress.
-Anti‑pollution serums – works well in lightweight, water‑based serums targeting urban stress and UV exposure
-Anti‑aging products – used in creams and serums aimed at skin firmness and radiance
-Soothing and recovery creams – added to post‑procedure or sensitive‑skin formulas to support barrier recovery
-Eye contour products – low irritation potential makes it suitable for gels and creams around the eye area
High chiral purity and consistent biological activity make this compound a reliable material for research and synthesis.
-Cell biology research – used in studies on oxidative stress, insulin signaling, and mitochondrial function
-Analytical reference standard – serves as a certified standard for chiral purity testing and quality control
-Specialty intermediate – acts as a building block for more complex bioactive molecules
-Helps manage blood sugar and supports diabetes care
-Protects liver function by reducing oxidative damage and supporting antioxidant enzyme activity
-Supports cognitive function in aging populations through antioxidant and anti‑inflammatory pathways
-Slows visible signs of aging—supports skin elasticity, reduces fine lines, and helps maintain a youthful appearance
-Aids energy metabolism, supports fat burning, and helps convert sugar into usable energy—useful in fatigue management and weight control
-Provides general support for heart health and may play a role in reducing inflammation linked to conditions like allergies or arthritis
Q&A
Q1: What is the primary industrial advantage of using the sodium salt form over standard R-Lipoic Acid?
A1: The sodium salt provides superior thermal stability, preventing unwanted polymerization during manufacturing processes (e.g., heating, drying). This ensures consistent product quality and greater flexibility in formulation development.
Q2: What are the key physicochemical specifications for industrial-grade R-Alpha Lipoic Acid Sodium Salt?
A2: Key specifications include: Assay (HPLC) ≥ 99.0%, R-enantiomer content > 99.4%, specific optical rotation [α]D between +60° and +85°, loss on drying ≤ 3.0%, and heavy metals ≤ 10 ppm.
Q3: What are the recommended storage conditions for this material?
A3: For optimal stability, store in a tightly sealed original container, in a cool, dry, and well-ventilated area. Protect from light and moisture. Keep away from ignition sources and incompatible materials like strong oxidizing agents.
Q4: In which types of cosmetic formulations is this ingredient most effectively incorporated?
A4: Due to its excellent water solubility, it integrates seamlessly into aqueous-based systems such as serums, toners, gels, and emulsions. It is ideally added to the water phase during manufacturing at temperatures below 40°C to maintain its integrity.
Q5: Why is chirality (R-form) critically important for this molecule?
A5: Biological systems exhibit stereoselectivity. The R-enantiomer is the naturally occurring and biologically active form, recognized by enzymes and receptors in the human body. The S-enantiomer, present in racemic mixtures, lacks this biological relevance.
