Vitamin K Supplement Vitamin K1 Phytonadione Vitamin K1 Oil CAS 81818-54-4

Introduction：

Phytonadione is the naturally occurring, plant-derived form of Vitamin K, recognized for its biochemical role in hepatic carboxylation reactions. The compound is inherently photosensitive, requiring strict light-protective measures during processing, storage, and transportation to maintain integrity.

Phytonadione is formulated into sterile injectable emulsions for acute-care use, as well as into oral tablets, softgels, and gummies for daily nutritional support. In personal care and food applications, the compound is incorporated into topical serums, creams, and recovery balms, and is also used to fortify edible oils, dairy analogs, and sports nutrition products. Veterinary premixes for livestock and poultry feed represent an additional application segment, where the ingredient is included at species-specific supplementation levels.

Specification:

Application

1. Pharmaceutical Injectable Emulsions

-Sterile formulations for parenteral delivery in acute-care settings where rapid systemic availability is required.

-The oil-soluble active is emulsified using suitable solubilizers to produce stable aqueous dispersions for intravenous, intramuscular, or subcutaneous administration. Available strengths include 10 mg/mL for general use and 1 mg/0.5 mL for neonatal applications. 

Formulation parameters include endotoxin control, low aluminum content (≤100 mcg/L), and optional preservative-free presentations. The emulsion must be protected from light throughout the manufacturing and administration process.

2. Nutraceutical Oral Dosage Forms

-Dietary supplements and multivitamin blends for maintenance of normal physiological functions.

-Incorporated into tablets, softgel capsules, or gummies at micro-dosage levels (90–120 mcg per adult serving). Formulation approaches include microencapsulation, cold-tableting, and adsorption onto porous carriers to enhance stability and bioavailability. 

The lipophilic nature requires careful excipient selection and manufacturing sequencing to ensure homogeneous distribution and protection against oxidative degradation over shelf life.

3. Cosmetic and Topical Skincare Products

-Topical preparations targeting microcirculation support, post-procedure recovery, and visible improvement of vascular imperfections.
-Integrated into eye serums, anti-aging creams, and recovery balms following cosmetic procedures. Nano-emulsion systems enable dermal penetration of the oil-soluble active. 

The compound's affinity for lipid barriers supports formulations aimed at improving local peripheral circulation. Applications include reduction of post-procedural bruising and under-eye discoloration. 

Patch-testing protocols are recommended due to potential delayed hypersensitivity.

4. Functional Foods and Oil-Based Fortification

-Fortification of edible oils, dairy analogs, sports nutrition products, and other lipid-containing food matrices.

-Blended directly into oil phases or applied via spray-dried beadlets. 

The compound exhibits good oxidative stability in high-oleic oil systems and imparts no off-taste or color changes to finished goods. 

Processing parameters must account for light exposure and thermal stability during extrusion or pasteurization.

5. Veterinary Premixes and Animal Feed

-Large-scale nutritional supplementation in livestock and poultry production.

-Diluted with carriers such as starch or cellulose for homogeneous mixing into pelleted or mash feeds. The formulation must withstand the shear heat of feed extrusion while maintaining active integrity. 

Dosages comply with species-specific nutritional guidelines across poultry, swine, and ruminant operations. Batch-to-batch potency consistency and thermal stability are key quality metrics.

Q&A

Q1: What does Vitamin K1 actually do in the body?
A1: Vitamin K1 acts as a helper in the liver to activate certain proteins that are involved in normal physiological processes. These include proteins related to blood and bone metabolism. Without adequate Vitamin K1, these proteins cannot function properly.

Q2: What grades of Phytonadione are available?
A2: Pharmaceutical grade (USP/EP) – for injectable use. Food grade – for supplements and oral products. Cosmetic grade – for skincare formulations, with extra care on odor and color. Feed grade – for animal nutrition. All grades are produced under GMP standards with full test reports.

Q3: Why does the material need to be protected from light?
A3: Vitamin K1 breaks down quickly when exposed to light. Even ordinary indoor lighting over time can reduce its strength. That is why the material is packed in amber glass or opaque containers and must be kept away from light during storage and handling.

Q4: Can this be used in water-based products like clear serums or drinks?
A4: Not directly, because Vitamin K1 does not dissolve in water. To use it in water-based formulas, it must be emulsified with suitable agents such as polysorbates or lecithin. Pre-made emulsion concentrates are also available for easier processing.

Q5: Are there any ingredients or conditions that should be avoided during formulation?
A5: Vitamin K1 may react with oxidizing agents and certain metal ions such as iron and copper. Strong alkaline conditions should also be avoided. In multi-ingredient blends, it is best to separate it from reactive minerals or use protective agents. Processing should be done away from strong light and excessive heat.

Q6: Is Vitamin K1 approved for use in different countries?
A6: Yes, Vitamin K1 is widely recognized in major markets. In the US, it is accepted as a drug substance (USP), a dietary supplement ingredient, and a food additive. In the EU, it is listed for food fortification and in the cosmetic ingredient database. Compliance with USP, EP, or JP standards can be arranged as needed.