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20% Calcium
Nanjing Gemsen
CAS 35947-07-0
Introduction：
Product name | Calcium Bisglycinate |
Synonyms | Calcium Glycinate |
Appearance | White Powder |
| CAS No. | 35947-07-0 |
| Molecular Formula | C2H7CaNO2 |
| Purity | 20%min Calcium |
Sample | Available |
Calcium bisglycinate (bisglycinate calcium chelate) is a third generation calcium compound formed by reacting calcium with the amino acid glycine, creating a stable 1:2 chelated structure confirmed by FT IR spectroscopy. This structure yields a white crystalline powder with high water solubility and a neutral taste. Unlike conventional calcium sources such as carbonate or citrate, its absorption does not depend on gastric acid; the chelated form remains stable across varying pH levels and is absorbed via amino acid transport pathways in the small intestine. This mechanism ensures efficient bioavailability and compatibility with diverse dietary patterns and digestive conditions. The product is primarily used as a mineral ingredient in dietary supplements, functional foods, and specialised nutritional products.
Specification:
| Items | Specifications | Methods |
| Appearance | White powder | Visual |
| Identification | Concordant with the reference spectrum | FT-IR |
| Calcium ( (on dried basis), w/% | ≥20.0 | ICP - OES |
| Loss on drying, w/% | ≤9.0 | USP |
| PH | 10.0~12.0 | USP |
| Bulk density, g/ml | ≥0.50 | Balance |
| Tapped density, g/ml | ≥0.80 | Balance |
| Particle size, w/% | 90% passing 60 mesh | Sieving |
| Heavy metals, mg/kg | ≤10 | USP |
| Pb, mg/kg | ≤1 | ICP - MS |
| As, mg/kg | ≤1 | ICP - MS |
| Cd, mg/kg | ≤1 | ICP - MS |
| Hg, mg/kg | ≤0.1 | ICP - MS |
| Total viable count, cfu/g | ≤1000 | USP |
| Yeast and mould, cfu/g | ≤25 | USP |
| Coliform bacteria, /g | Negative | USP |
| Escherichia coli, /g | Negative | USP |
| Salmonella, /10g | Negative | USP |
| Staphylococcus aureus, /g | Negative | USP |
Enterrobater sakazaki, /g | Negative | USP |
| Shigella castellani, /g | Negative | USP |
1. Dietary Supplements
Calcium bisglycinate is widely incorporated into dietary supplements aimed at supporting bone health, muscle function, and overall mineral nutrition. Its high bioavailability allows for lower effective doses, enabling manufacturers to develop products with reduced tablet sizes or improved nutrient density. The ingredient is suitable for:
·Standalone calcium products: Tablets, capsules, powders, and effervescent formulations.
·Multi-nutrient complexes: Compatible with vitamins and other minerals without significant interaction.
·Life-stage specific formulations: Used in products targeting prenatal and postnatal needs, aging populations, and women's health.
2. Functional Foods and Beverages
Due to its excellent solubility and neutral taste, calcium bisglycinate is well suited for fortifying a variety of food and beverage products without altering sensory qualities. It is commonly applied in:
·Plant-based milks and beverages: Provides consistent calcium levels while maintaining a smooth mouthfeel.
·Nutrition bars and snacks: Allows uniform fortification without affecting texture or flavor.
·Meal replacements and powdered drinks: Ensures rapid dispersion and stability in liquid systems.
3. Specialized Nutrition
Calcium bisglycinate is often selected for products designed for individuals with specific nutritional requirements or digestive sensitivities. Its pH-independent absorption and gentle nature make it appropriate for:
·Formulations for those with low stomach acid or digestive discomfort.
·Vegan and lactose free products: Offers a plant sourced compatible calcium option.
·Products supporting digestive wellness: Provides a non irritating mineral source.
Q1: How does the absorption of calcium bisglycinate compare to other calcium forms?
A1: Calcium bisglycinate is designed for efficient absorption. Its chelated structure protects the calcium ion from binding with dietary factors such as phytates and oxalates, and it is absorbed via amino acid transporters in the intestinal wall. Studies indicate that its bioavailability can be significantly higher than that of calcium carbonate, allowing for effective mineral delivery at lower doses.
Q2: Can calcium bisglycinate be taken on an empty stomach?
A2: Yes. Because its absorption does not rely on gastric acid, it can be taken without food. This makes it a practical option for individuals with sensitive stomachs or those using medications that reduce stomach acid production.
Q3: What is the recommended daily intake of calcium bisglycinate?
A3: The appropriate intake depends on the target consumer's elemental calcium needs, which typically range from 800 to 1000 mg per day for adults. Due to its high bioavailability, a smaller amount of calcium bisglycinate may achieve the same nutritional goal. To optimize utilization, daily intake is often divided into two or three servings. Formulators should consult current dietary guidelines and adjust product labels accordingly.
Q4: What nutrients work well with calcium bisglycinate?
A4: Calcium bisglycinate is often combined with vitamin D3, vitamin K2, and magnesium in formulations aimed at comprehensive bone and mineral support. Vitamin D3 supports calcium absorption, vitamin K2 helps direct calcium to bone tissue, and magnesium participates in the activation of these vitamins. These synergistic combinations are common in premium nutritional products.
Q5: What are the manufacturing advantages of using GEMSEN calcium bisglycinate powder?
A5: GEMSEN calcium bisglycinate is produced as a fine, free flowing powder with high purity and consistent particle size. Its excellent solubility and neutral organoleptic properties facilitate incorporation into various manufacturing processes, including direct compression, wet granulation, and liquid mixing. This versatility helps manufacturers achieve uniform nutrient distribution and stable end products.
Q6: Why is calcium bisglycinate considered gentle on the gastrointestinal system?
A6: The chelated structure of calcium bisglycinate allows it to be absorbed without requiring stomach acid, reducing potential irritation of the gastric mucosa. Additionally, its near neutral pH minimizes any alteration of stomach acidity, which contributes to its good tolerability and lowers the likelihood of common digestive discomforts such as bloating or constipation.
