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99%min L-Choline Bitartrate
Nanjing Gemsen
CAS 87-67-2
Introduction：
| Product Name | L-Choline Bitartrate |
| Appearance | White, Hydroscopic, Crystalline powder |
| CAS No. | 87-67-2 |
| Molecular formul | C9H19NO7 |
| Molecular weight | 253.25 |
| Purity | 99% L-Choline Bitartrate |
| Sample | Available |
L-Choline Bitartrate, a stable, water-soluble salt formed by the conjugation of choline and L-(+)-tartaric acid, stands as one of the most prevalent and cost-effective dietary choline supplements, containing approximately 41% elemental choline by weight. As an essential nutrient that the human body cannot synthesize in sufficient quantities to meet physiological demands, it serves as a critical precursor to acetylcholine (ACh)—a neurotransmitter foundational to memory, learning, and neuromuscular communication—and plays pivotal roles in phospholipid synthesis (e.g., phosphatidylcholine), methyl group metabolism, and lipid transport. Its crystalline structure allows for easy formulation into powders, capsules, and multi-nutrient blends, making it a staple in nootropic stacks, pre-workout supplements, and daily multivitamins, while its bioavailability ensures efficient absorption in the intestines to elevate plasma choline levels.
Specification:
Items | Specifications | Method |
Appearance | White, Hydroscopic, Crystalline powder | Visual |
| Assay | 99%-100.5% on the anhydrous basis | USP<541> |
pH(1 in 10) | 3.0-4.0 | USP<791> |
Water | ≤ 0.5% | USP<731> |
Residue on Ignition | ≤ 0.1% | USP<281> |
Specific Rotation | +17.5°- +18.5° | USP<781S> |
1,4-dioxane | ≤10μg/g | USP<467> |
Limit of Total Amines | ≤10μg/g | USP |
Heavy Metals | ≤ 10ppm | USP<231> |
Lead | ≤ 0.3ppm | USP<730> |
Arsenic | ≤ 1ppm | USP<730> |
Cadmium | ≤ 0.2ppm | USP<730> |
| Mercury | ≤ 0.1ppm | USP<730> |
| Total Plate Count | ≤1000CFU/g | USP<61> |
| Yeast and Mold | ≤100CFU/g | USP<61> |
| E.Coli | Negative/10g | USP<62> |
| Salmonella | Negative/25g | USP<62> |
| Staphylococcus aureus | Negative/10g | USP<62> |
| Individual Impurity | ≤ 0.3% | USP |
| Total Impurities | ≤ 2% | USP |
| Particle Size | 100%Through 20 mesh | USP<786> |
| Bulk Density | As the result | USP<616> |
| Tapped Density | As the result | USP<616> |
Function and Application:
1. Supporting Cognitive Function: By acting as a direct precursor to acetylcholine, L-Choline Bitartrate fuels the synthesis of this neurotransmitter in the brain, thereby enhancing memory recall, attention span, and information processing—effects particularly notable in individuals with suboptimal dietary choline intake. While its ability to cross the blood-brain barrier is limited by saturable CTL1 transporters, it effectively sustains baseline cholinergic activity, and when combined with cholinesterase inhibitors or certain nootropics, may synergistically boost cognitive performance. It is commonly formulated into capsules, chewables, and powdered supplements tailored for students, professionals, and older adults seeking to maintain mental clarity.
2. Protecting Liver Health: Choline Bitartrate plays a vital role in hepatic lipid metabolism by facilitating the production of very low-density lipoproteins (VLDL), which prevent fat accumulation in the liver and reduce the risk of non-alcoholic fatty liver disease (NAFLD). For individuals with choline deficiency—often linked to poor diet or chronic liver conditions—it reverses hepatic abnormalities and supports detoxification processes, making it a key ingredient in liver-support supplements, often paired with compounds like TUDCA for enhanced efficacy.
3. Enhancing Neuroprotection: Beyond neurotransmitter synthesis, Choline Bitartrate contributes to the structural integrity of neuronal cell membranes by supporting phosphatidylcholine and sphingomyelin production, while its anti-inflammatory properties mitigate brain inflammation associated with neurodegenerative processes (e.g., Alzheimer's and Parkinson's diseases). It regulates the synthesis of platelet-activating factor (PAF), a signaling molecule linked to neuroinflammation, thereby shielding neurons from damage and promoting long-term brain health.
4. Supporting Prenatal Development: Adequate choline intake via L-Choline Bitartrate is critical for fetal brain development, as it fosters neural connection formation and optimizes cortical maturation. Pregnant women supplementing with this form of choline may reduce the risk of neural tube defects in offspring and support postnatal cognitive outcomes, including memory and learning abilities in childhood. It is often recommended as a targeted supplement for expectant mothers, aligned with dietary reference intakes of 450–550 mg/day.
5. Boosting Physical Performance: For athletes and fitness enthusiasts, Choline Bitartrate aids in muscle recovery and mental-muscle connection by supporting acetylcholine-mediated neuromuscular communication, reducing exercise-related fatigue, and enhancing focus during training. It is frequently incorporated into pre-workout formulas (e.g., alongside caffeine or amino acids) to improve strength output and endurance, while its role in methylation supports energy metabolism and cellular repair post-exercise.
6. Supporting Cardiovascular and Metabolic Health: By participating in one-carbon metabolism, Choline Bitartrate acts as a methyl donor to convert homocysteine to methionine, lowering circulating homocysteine levels—a known risk factor for cardiovascular disease. It also supports cell membrane fluidity across tissues, contributing to overall metabolic homeostasis, and is often included in heart-healthy supplement blends due to its synergistic effects with B vitamins (e.g., B12, folate) in methyl group metabolism.
Introduction：
| Product Name | L-Choline Bitartrate |
| Appearance | White, Hydroscopic, Crystalline powder |
| CAS No. | 87-67-2 |
| Molecular formul | C9H19NO7 |
| Molecular weight | 253.25 |
| Purity | 99% L-Choline Bitartrate |
| Sample | Available |
L-Choline Bitartrate, a stable, water-soluble salt formed by the conjugation of choline and L-(+)-tartaric acid, stands as one of the most prevalent and cost-effective dietary choline supplements, containing approximately 41% elemental choline by weight. As an essential nutrient that the human body cannot synthesize in sufficient quantities to meet physiological demands, it serves as a critical precursor to acetylcholine (ACh)—a neurotransmitter foundational to memory, learning, and neuromuscular communication—and plays pivotal roles in phospholipid synthesis (e.g., phosphatidylcholine), methyl group metabolism, and lipid transport. Its crystalline structure allows for easy formulation into powders, capsules, and multi-nutrient blends, making it a staple in nootropic stacks, pre-workout supplements, and daily multivitamins, while its bioavailability ensures efficient absorption in the intestines to elevate plasma choline levels.
Specification:
Items | Specifications | Method |
Appearance | White, Hydroscopic, Crystalline powder | Visual |
| Assay | 99%-100.5% on the anhydrous basis | USP<541> |
pH(1 in 10) | 3.0-4.0 | USP<791> |
Water | ≤ 0.5% | USP<731> |
Residue on Ignition | ≤ 0.1% | USP<281> |
Specific Rotation | +17.5°- +18.5° | USP<781S> |
1,4-dioxane | ≤10μg/g | USP<467> |
Limit of Total Amines | ≤10μg/g | USP |
Heavy Metals | ≤ 10ppm | USP<231> |
Lead | ≤ 0.3ppm | USP<730> |
Arsenic | ≤ 1ppm | USP<730> |
Cadmium | ≤ 0.2ppm | USP<730> |
| Mercury | ≤ 0.1ppm | USP<730> |
| Total Plate Count | ≤1000CFU/g | USP<61> |
| Yeast and Mold | ≤100CFU/g | USP<61> |
| E.Coli | Negative/10g | USP<62> |
| Salmonella | Negative/25g | USP<62> |
| Staphylococcus aureus | Negative/10g | USP<62> |
| Individual Impurity | ≤ 0.3% | USP |
| Total Impurities | ≤ 2% | USP |
| Particle Size | 100%Through 20 mesh | USP<786> |
| Bulk Density | As the result | USP<616> |
| Tapped Density | As the result | USP<616> |
Function and Application:
1. Supporting Cognitive Function: By acting as a direct precursor to acetylcholine, L-Choline Bitartrate fuels the synthesis of this neurotransmitter in the brain, thereby enhancing memory recall, attention span, and information processing—effects particularly notable in individuals with suboptimal dietary choline intake. While its ability to cross the blood-brain barrier is limited by saturable CTL1 transporters, it effectively sustains baseline cholinergic activity, and when combined with cholinesterase inhibitors or certain nootropics, may synergistically boost cognitive performance. It is commonly formulated into capsules, chewables, and powdered supplements tailored for students, professionals, and older adults seeking to maintain mental clarity.
2. Protecting Liver Health: Choline Bitartrate plays a vital role in hepatic lipid metabolism by facilitating the production of very low-density lipoproteins (VLDL), which prevent fat accumulation in the liver and reduce the risk of non-alcoholic fatty liver disease (NAFLD). For individuals with choline deficiency—often linked to poor diet or chronic liver conditions—it reverses hepatic abnormalities and supports detoxification processes, making it a key ingredient in liver-support supplements, often paired with compounds like TUDCA for enhanced efficacy.
3. Enhancing Neuroprotection: Beyond neurotransmitter synthesis, Choline Bitartrate contributes to the structural integrity of neuronal cell membranes by supporting phosphatidylcholine and sphingomyelin production, while its anti-inflammatory properties mitigate brain inflammation associated with neurodegenerative processes (e.g., Alzheimer's and Parkinson's diseases). It regulates the synthesis of platelet-activating factor (PAF), a signaling molecule linked to neuroinflammation, thereby shielding neurons from damage and promoting long-term brain health.
4. Supporting Prenatal Development: Adequate choline intake via L-Choline Bitartrate is critical for fetal brain development, as it fosters neural connection formation and optimizes cortical maturation. Pregnant women supplementing with this form of choline may reduce the risk of neural tube defects in offspring and support postnatal cognitive outcomes, including memory and learning abilities in childhood. It is often recommended as a targeted supplement for expectant mothers, aligned with dietary reference intakes of 450–550 mg/day.
5. Boosting Physical Performance: For athletes and fitness enthusiasts, Choline Bitartrate aids in muscle recovery and mental-muscle connection by supporting acetylcholine-mediated neuromuscular communication, reducing exercise-related fatigue, and enhancing focus during training. It is frequently incorporated into pre-workout formulas (e.g., alongside caffeine or amino acids) to improve strength output and endurance, while its role in methylation supports energy metabolism and cellular repair post-exercise.
6. Supporting Cardiovascular and Metabolic Health: By participating in one-carbon metabolism, Choline Bitartrate acts as a methyl donor to convert homocysteine to methionine, lowering circulating homocysteine levels—a known risk factor for cardiovascular disease. It also supports cell membrane fluidity across tissues, contributing to overall metabolic homeostasis, and is often included in heart-healthy supplement blends due to its synergistic effects with B vitamins (e.g., B12, folate) in methyl group metabolism.