 |
| Quantity: | |
|---|---|
99% L-5-Methyltetrahydrofolate Calcium
Nanjing Gemsen
CAS 151533-22-1
Introduction：
Product name | L-5-Methyltetrahydrofolate Calcium |
Synonyms | methylfolate |
Appearance | White to light yellow crystalline powder,odorless |
Purity | 99% L-5-Methyltetrahydrofolate Calcium |
MOQ | 1 KG |
L-5-Methyltetrahydrofolate Calcium is the active and bioavailable form of folate (Vitamin B9), is a stabilized calcium salt that can be directly utilized by the body without the need for enzymatic conversion by MTHFR. This allows it to efficiently bypass metabolic bottlenecks common in individuals with MTHFR gene mutations, ensuring reliable delivery of active folate across cell membranes and the blood-brain barrier.
As the primary circulating form of folate in the human body, L-Methylfolate serves as a critical cofactor in one-carbon metabolism. It plays a central role in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. Furthermore, it is essential for the remethylation of homocysteine to methionine, a process vital for DNA synthesis, repair, and methylation cycles.
Specification:
| Items | Specifications | Methods | |
| 1. Appearance | White to light yellow crystalline powder,odorles | Visual | |
| 2. Identification | Infrared detection | IR | |
Calcium detection | USP43 | ||
The retention time of HPLC main peak was in line with the standard | USP43 | ||
| 3. Content (on dried basis) | 95.0%~102.0% | USP43 | |
| 4. Water | 6.0%~17.0% | USP43 | |
| 5. Calcium (on dry basis) | 7.0%~8.5% | USP43 | |
6. Impurities | 4-aminobenzoyl-glutamic acid | ≤0.5% | USP43 |
4-α-Hydroxy-5-methyltetrahydrofolic acid | ≤1.0% | USP43 | |
(6S,R)-Mefox | ≤1.0% | USP43 | |
Tetrahydrofolic acid | ≤0.5% | USP43 | |
7,8-Dihydrofolic acid | ≤0.5% | USP43 | |
Folic acid | ≤0.5% | USP43 | |
5,10-methylenetetrahydrofolic acid | ≤0.5% | USP43 | |
5-methyltetrahydrop teroic acid | ≤0.5% | USP43 | |
| Dimethyltetrahydrofolic acid | ≤0.15% | USP43 | |
Total impurities | ≤2.5% | USP43 | |
| 7. Heavy Metals | ≤20 mg/kg | USP43 | |
| 8.Elemental Impurities | Plumbum | ≤1.0 mg/kg | USP43 |
Arsenic | ≤1.5 mg/kg | USP43 | |
Mercury | ≤1.5 mg/kg | USP43 | |
Cadmium | ≤1.5 mg/kg | USP43 | |
| Boron | ≤50 mg/kg | USP43 | |
| Platinum | ≤10 mg/kg | USP43 | |
| Chloride | ≤0.5% | USP43 | |
9. Residual Solvents (Ethanol) | ≤0.5% | USP43 | |
| 10. D-5-methyltetrahydrofolic Acid | ≤1.0% | USP43 | |
| 11. Microbial Limits | Total aerobic bacteria | ≤500 CFU/g | USP43 |
Total number of mold and yeast | ≤50 CFU/g | USP43 | |
Salmonella | Non-detectable | USP43 | |
Escherichia coli | Non-detectable | USP43 | |
Staphylococcus aureus | Non-detectable | USP43 | |
Pseudomonas aeruginosa | Non-detectable | USP43 | |
Candida albicans | Non-detectable | USP43 | |
Clostridia | Non-detectable | USP43 | |
Function and Application:
1. L-5-Methyltetrahydrofolate Calcium offers superior bioavailability for individuals with compromised folate metabolism, particularly those with MTHFR polymorphisms. It is clinically used to support neurological and mental health by serving as an adjunctive therapy in Major Depressive Disorder (MDD), where it has been shown to enhance the effectiveness of SSRIs in treatment-resistant cases at doses such as 15 mg/day.
2. As a crucialactive form for healthy fetal development during pregnancy, Methylfolate is a recommended alternative to folic acid for women of childbearing age, especially those with confirmed MTHFR mutations, as it effectively supports the prevention of Neural Tube Defects (NTDs) by ensuring the availability of metabolically active folate independent of the body's conversion efficiency.
3. L-5-Methyltetrahydrofolate Calcium supports cardiovascular and cellular health by regulating homocysteine metabolism. By facilitating the conversion of homocysteine to methionine, it helps maintain healthy homocysteine levels, which is a key factor for vascular integrity and reduced cardiovascular risk. It also contributes to overall methylation processes that are fundamental to DNA expression and cellular function.
4. Despite its benefits, L-5-Methyltetrahydrofolate Calcium requires careful dosing and medical supervision. It is incorporated into prescription medical foods, high-potency dietary supplements, and specialized prenatal formulas. Due to the risk of side effects like anxiety, insomnia, or irritability from over-methylation, its use is best guided by a healthcare professional to ensure safety and efficacy, particularly when addressing specific genetic or metabolic needs.
Introduction：
Product name | L-5-Methyltetrahydrofolate Calcium |
Synonyms | methylfolate |
Appearance | White to light yellow crystalline powder,odorless |
Purity | 99% L-5-Methyltetrahydrofolate Calcium |
MOQ | 1 KG |
L-5-Methyltetrahydrofolate Calcium is the active and bioavailable form of folate (Vitamin B9), is a stabilized calcium salt that can be directly utilized by the body without the need for enzymatic conversion by MTHFR. This allows it to efficiently bypass metabolic bottlenecks common in individuals with MTHFR gene mutations, ensuring reliable delivery of active folate across cell membranes and the blood-brain barrier.
As the primary circulating form of folate in the human body, L-Methylfolate serves as a critical cofactor in one-carbon metabolism. It plays a central role in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. Furthermore, it is essential for the remethylation of homocysteine to methionine, a process vital for DNA synthesis, repair, and methylation cycles.
Specification:
| Items | Specifications | Methods | |
| 1. Appearance | White to light yellow crystalline powder,odorles | Visual | |
| 2. Identification | Infrared detection | IR | |
Calcium detection | USP43 | ||
The retention time of HPLC main peak was in line with the standard | USP43 | ||
| 3. Content (on dried basis) | 95.0%~102.0% | USP43 | |
| 4. Water | 6.0%~17.0% | USP43 | |
| 5. Calcium (on dry basis) | 7.0%~8.5% | USP43 | |
6. Impurities | 4-aminobenzoyl-glutamic acid | ≤0.5% | USP43 |
4-α-Hydroxy-5-methyltetrahydrofolic acid | ≤1.0% | USP43 | |
(6S,R)-Mefox | ≤1.0% | USP43 | |
Tetrahydrofolic acid | ≤0.5% | USP43 | |
7,8-Dihydrofolic acid | ≤0.5% | USP43 | |
Folic acid | ≤0.5% | USP43 | |
5,10-methylenetetrahydrofolic acid | ≤0.5% | USP43 | |
5-methyltetrahydrop teroic acid | ≤0.5% | USP43 | |
| Dimethyltetrahydrofolic acid | ≤0.15% | USP43 | |
Total impurities | ≤2.5% | USP43 | |
| 7. Heavy Metals | ≤20 mg/kg | USP43 | |
| 8.Elemental Impurities | Plumbum | ≤1.0 mg/kg | USP43 |
Arsenic | ≤1.5 mg/kg | USP43 | |
Mercury | ≤1.5 mg/kg | USP43 | |
Cadmium | ≤1.5 mg/kg | USP43 | |
| Boron | ≤50 mg/kg | USP43 | |
| Platinum | ≤10 mg/kg | USP43 | |
| Chloride | ≤0.5% | USP43 | |
9. Residual Solvents (Ethanol) | ≤0.5% | USP43 | |
| 10. D-5-methyltetrahydrofolic Acid | ≤1.0% | USP43 | |
| 11. Microbial Limits | Total aerobic bacteria | ≤500 CFU/g | USP43 |
Total number of mold and yeast | ≤50 CFU/g | USP43 | |
Salmonella | Non-detectable | USP43 | |
Escherichia coli | Non-detectable | USP43 | |
Staphylococcus aureus | Non-detectable | USP43 | |
Pseudomonas aeruginosa | Non-detectable | USP43 | |
Candida albicans | Non-detectable | USP43 | |
Clostridia | Non-detectable | USP43 | |
Function and Application:
1. L-5-Methyltetrahydrofolate Calcium offers superior bioavailability for individuals with compromised folate metabolism, particularly those with MTHFR polymorphisms. It is clinically used to support neurological and mental health by serving as an adjunctive therapy in Major Depressive Disorder (MDD), where it has been shown to enhance the effectiveness of SSRIs in treatment-resistant cases at doses such as 15 mg/day.
2. As a crucialactive form for healthy fetal development during pregnancy, Methylfolate is a recommended alternative to folic acid for women of childbearing age, especially those with confirmed MTHFR mutations, as it effectively supports the prevention of Neural Tube Defects (NTDs) by ensuring the availability of metabolically active folate independent of the body's conversion efficiency.
3. L-5-Methyltetrahydrofolate Calcium supports cardiovascular and cellular health by regulating homocysteine metabolism. By facilitating the conversion of homocysteine to methionine, it helps maintain healthy homocysteine levels, which is a key factor for vascular integrity and reduced cardiovascular risk. It also contributes to overall methylation processes that are fundamental to DNA expression and cellular function.
4. Despite its benefits, L-5-Methyltetrahydrofolate Calcium requires careful dosing and medical supervision. It is incorporated into prescription medical foods, high-potency dietary supplements, and specialized prenatal formulas. Due to the risk of side effects like anxiety, insomnia, or irritability from over-methylation, its use is best guided by a healthcare professional to ensure safety and efficacy, particularly when addressing specific genetic or metabolic needs.