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Most Popular Magnesium Supplement Magnesium L-Threonate CAS 778571-57-6

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  • 98%min Magnesium L-Threonate

  • Nanjing Gemsen

  • CAS 778571-57-6

Introduction:

Product Name

Magnesium L-Threonate

Appearance

White or almost white powder

CAS No.

778571-57-6

Molecular formul

C13H21NO15S

Molecular weight

294.5

Purity

98%min Magnesium L-Threonate

Sample Available


Most magnesium supplements work well for muscles and the heart, but barely reach the brain. 

Magnesium L‑threonate is different. It couples magnesium with L‑threonic acid, a natural vitamin C metabolite, allowing efficient passage across the blood‑brain barrier. Conventional forms like citrate or glycinate raise blood magnesium – not cerebrospinal fluid levels. Magnesium L‑threonate does. Available as a white to off‑white powder or in capsules, a daily intake of 1–2 g supplies about 75–145 mg of elemental magnesium. 

Every batch from GEMSEN meets strict quality standards: no heavy metals, no unnecessary fillers.



Specification:


Items

Specifications

Results

Method

Character

A white to almost white

crystalline powder

white crystalline

powder

USP41

Loss on dry

<1.0%

0.6%

USP41<731>

Mg%

7.2% - 8.3%

8.29%

Titration

Magnesium L-threonate

≥98.0%

99.7%

USP41

PH

5.8-7.0

6.44

GB/T9724

Heavy metal

<10ppm

<10ppm

USP41<231>

Pb

≤0.5ppm

<0.5ppm

USP41<251>

Cd

≤0.5ppm

<0.5ppm

USP41<231>

Ash

<1.0%

0.31%

USP41<281>

As

<2ppm

<2ppm

USP41<211>

Hg

≤0.1ppm

<0.1ppm

USP41<261>

Total Plate Count

≤1000cfu/g

<1000cfu/g

USP41<2021>/<2022>

Total Yeast&Mold

≤100cfu/g

<100cfu/g

USP41<2021>/<2022>

S. aureus

Negative

Negative

USP41<2021>/<2022>

E. Coliforms

Negative

Negative

USP41<2021>/<2022>

Salmonella

Negative

Negative

USP41<2021>/<2022>

Bulk Density

≥0.50g/ml

0.60g/ml

USP41<616>

Conclusion

Passed test according to the Standard of In-house.


Applications:


Demanding Mental Work

When to use: Exam periods, intensive training courses, high‑output project sprints.

Why it helps: Prolonged cognitive load depletes neuronal resources. Magnesium L‑threonate supports working memory and episodic memory formation. Reaction time and hand‑eye coordination also improve – relevant for typing, data entry, or operating instruments.




Better Sleep & Morning Recovery

When to use: Waking up tired despite 7–8 hours in bed; shift work, young parenthood, or age‑related sleep changes.

Why it helps: A 21‑day trial showed measurable increases in deep and REM sleep (Oura ring data). Users also reported easier awakening and higher daytime energy. (Note: a separate 6‑week study found no objective sleep change – the effect may be strongest in those over 35 or with noticeable sleep dissatisfaction.)




High‑Pressure Lifestyles

When to use: Irregular hours, frequent time‑zone travel, or emotionally demanding roles (aircrew, emergency response, executive leadership).

Why it helps: A controlled trial reported a lower sleep‑time heart rate (‑1.3 bpm) and increased HRV – a marker of vagal tone. These changes point to better autonomic recovery during rest.




Everyday Memory Comfort – Natural Aging

When to use: Healthy adults over 50 who occasionally forget names, appointments, or where items were placed – without any diagnosed condition.

Why it helps: A 12‑week study in adults aged 50–70 produced a large effect size (Cohen’s d = 0.91) on composite cognitive scores. Estimated “cognitive age” reversed by roughly 9 years versus placebo. A 30‑day study also showed larger memory gains in older participants.




Fast Reaction & Hand‑Eye Coordination

When to use: Esports, competitive gaming, racquet sports, or any activity where split‑second responses matter.

Why it helps: In a 6‑week trial using a first‑person shooting simulation (3D Aim Trainer), the magnesium L‑threonate group improved their score by 6.3%, while placebo showed no change.




Frequently Asked Questions (Q&A)

Q1. How is magnesium L‑threonate different from ordinary magnesium?

Most magnesium salts (citrate, oxide, glycinate) raise blood magnesium but barely reach the brain. Magnesium L‑threonate does – thanks to its L‑threonate ligand. That is why its effects on memory, reaction speed, and sleep differ from ordinary magnesium.


Q2. Can magnesium L‑threonate be taken with other magnesium forms?

Generally not necessary. It already provides 75–145 mg of elemental magnesium per day – within the recommended intake for healthy adults. Adding other magnesium salts may increase the risk of loose stools without added brain benefits.


Q3. Does magnesium L‑threonate interact with food or drinks?
No known interactions with coffee, tea, or light meals. However, high‑dose calcium or iron supplements taken at the same time may compete for absorption. Separating them by at least 2 hours is a reasonable precaution.


Q4. Is it safe for long‑term daily use?

The longest published randomised trial lasted 12 weeks. Longer use has not been formally studied. However, as an essential nutrient with a clean safety record, ongoing daily use at recommended doses is considered safe. Periodic re‑evaluation is still prudent – as with any supplement.


Q5. What to do if a dose is missed?
If a dose is forgotten, take it as soon as remembered – unless it is almost time for the next dose. Do not double the amount. Consistent daily intake matters more than perfect timing.


Q6. Can vegetarians or vegans use it?
Yes. The capsules used in clinical studies contained rice flour and stearic acid (plant‑derived). GEMSEN offers vegetable‑based capsule options. No animal‑derived ingredients are required for the active compound.


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